osteoporosis. 3. Engdahl C et al. Östrogen skyddar mot artrit och inflammationsmedierad benförlust via östrogen receptor alfa. 4. Klingberg E et al. Impaired

One of the most important of the secondary causes of osteoporosis is chronic exposure to glucocorticoids, which are used for an extraordinarily large number of disorders. The adverse effects of hypercortisolism on bone metabolism were recognized more than half a century ago ( 1 ).

The pathogenesis of secondary osteoporosis is almost always multifactorial. Certain endocrinopathies, systemic diseases, malignant neoplasias, organ dysfunctions, a variety of medications such as corticosteroids, lifestyle conditions and habits, and also major depression can lead to the secondary osteoporosis. Osteoporosis is a skeletal disease characterized by decreased bone mass and microarchitectural changes in bone tissue that increase the susceptibility to fracture. Secondary osteoporosis is loosely defined as low bone mineral density or increased risk of fragility fracture caused by any factor other than aging or postmenopausal status.

Secondary osteoporosis pathogenesis

Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to. av AA Pioszak · 2008 · Citerat av 258 — From the front view, the secondary structure elements of the PTH1R ECD are A common structural mechanism of hormone recognition appears to emerge PTH mimics for the treatment of osteoporosis and hypercalcemia. av K Thorarinsdottir · 2019 — modified peptide, now considered a foreign antigen, is carried to a secondary as cardiovascular disease, infections, osteoporosis and lymphoma, which is in. av A Stavropoulos · 2018 · Citerat av 38 — and are predominantly used in the treatment of osteoporosis and rarely, in some types of cancers, for the prevention of secondary osteoporosis. Diagnosis and treatment of primary hypothyreoidism. BMJ 2009;26:338 TA087 Osteoporosis – secondary prevention – NICE Guidance. January 2005.

Diagnosis and treatment of primary hypothyreoidism. BMJ 2009;26:338 TA087 Osteoporosis – secondary prevention – NICE Guidance. January 2005.

Up to 30% of postmenopausal women and 50% of men with osteoporosis may have an underlying cause. The underlying pathogenesis of secondary osteoporosis is often multifactorial. Secondary osteoporosis may result from endocrine abnormalities, such as hyperthyroidism, hypogonadism, Cushing's syndrome (see Chapters 45 and 46), and hyperparathyroidism (see Chapter 50). In addition, some chronic conditions, such as malabsorption, immobilization, hepatic, and renal disease (see Chapter 49) can result in bone loss.

Osteoporosis can be classified into 1) groups of conditions without known etiology, 2) specific disorders which result in osteoporosis with a well understood pathogenesis, and 3) specific disorders which result in osteoporosis but the pathogenesis is not understood.1 OSTEOPOROSIS WITH NO KNOWN ETIOLOGY OR ASSOCIATED DISEASES Idiopathic Juvenile

The most common causes of secondary osteoporosis in women are primary hyperparathyroidism and glucocorticoid use. Men are more likely to have a secondary cause of osteoporosis than women; as many as 50% of osteoporotic men may have a secondary cause. Secondary osteoporosis results from specific clinical disorders that are potentially reversible. Up to 30% of postmenopausal women and 50% of men with osteoporosis may have an underlying cause.

Klingberg E et al.
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But sometimes, symptoms appear. Learn about the types and symptoms of osteoporosis. Osteoporosis often starts silently and may not be found until a bone fractur Get the basics on osteoporosis -- including causes, symptoms, treatment, and prevention -- from the experts at WebMD.

The calcium demands of the growing fetus are given priority. Co-mordbidity with Other Secondary osteoporosis can be caused by an identifiable agent such as glucocorticoids, or by a disease such as hyperthyroidism or myeloma.
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av L WILHELMSEN · 1997 · Citerat av 166 — presentation is strongly related to statin use for secondary prevention, is a long-term cause of osteoporotic fracture, Osteoporosis International, and Brain Pathogenesis, Current Gerontology and Geriatrics Research,

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Due to increasing knowledge on pathogenetic factors causing osteoporosis and increasingly more detailed investigations, the diagnosis of secondary osteoporosis is being made increasingly more often. A rational search for the underlying disease or the bone-damaging medication is indicated particularly in adolescents, premenopausal women, men and postmenopausal women with rapidly decreasing bone

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. acute compression fracture or who present with a di agnosis of osteoporosis by BMD measurement. The most common causes of secondary osteoporosis in women are primary hyperparathyroidism and glucocorticoid use. Men are more likely to have a secondary cause of osteoporosis than women; as many as 50% of osteoporotic men may have a secondary cause. Secondary osteoporosis results from specific clinical disorders that are potentially reversible. Up to 30% of postmenopausal women and 50% of men with osteoporosis may have an underlying cause. The underlying pathogenesis of secondary osteoporosis is often multifactorial.